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Search Results for " inflammatory factors "

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12

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8

天然化合物

15

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2

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カタログ番号 製品名 別名 ターゲット
T64336 Izilendustat HIF/HIF Prolyl-Hydroxylase
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
T0446 Naphazoline hydrochloride Albalon,Rhinantin,Naphazoline HCl Adrenergic Receptor
Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.
T61233 Penehyclidine hydrochloride Penequinine hydrochloride NF-κB , AChR
Penehyclidine hydrochloride (Penequinine hydrochloride) is an M1 and M3 antagonist and activates NF-κB in lung tissue. Penehyclidine hydrochloride inhibits the release of inflammatory factors and shows anticholinergic pr...
T1482 Ciclopirox HOE296b ATPase , Ferroptosis , Antibacterial , Autophagy , Antifungal
Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spect...
T9543 Syk Inhibitor II hydrochloride Others
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...
T12848 SB-657510 Others , Neurotensin Receptor
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting U...
T63006 DHU-Se1
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 stimulates the release of reactive selenium compounds from macrophages and reduces the expression of cellular inflammatory factors such as iNOS and TNF-α. DHU-Se1 bloc...
T62364 CSF1R-IN-5
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases.
T62342 CSF1R-IN-4
CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40.
T72102 Glucocorticoid receptor modulator 1
Glucocorticoid receptor modulator 1 is a potent, orally active, non-steroidal selective glucocorticoid receptor modulator, exhibiting IC50 values of 9 nM and 130 nM against NF-κB and AP-1, respectively. It effectively re...
T78732 BO-1
BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus. It synergizes with antibiotics like Ciprofloxacin, reversing resistance in antibiotic-resistant...
T74799 NF-κB-IN-8 NF-κB
NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, inclu...
カタログ番号 製品名 別名 ターゲット
T3887 Rosarin Others
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .
TN4234 Hydrangenol NOS , NF-κB , Nrf2 , NO Synthase , Antifection , Autophagy
T6S1049 Wilforine ATPase
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi...
T1611 Isotretinoin 13-cis-Retinoic acid Retinoid Receptor , Endogenous Metabolite , Autophagy
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...
T9113 Myristicin Myristicine IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ...
T3123 Allicin ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
TN5369 Dehydroleucodine Dehydroleucodin
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a...
TN3070 4beta-Hydroxywithanolide E PARP , HSP , NF-κB , COX
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-00327 M-CSF/CSF1 Protein, Human, Recombinant (His) Human HEK293 Cells
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th...
TMPY-02028 RON/CD136 Protein, Human, Recombinant (His) Human HEK293 Cells
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPJ-00623 BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc) Rhesus HEK293 Cells
TNFSF13B is also known as B-cell activating factor (BAFF), BLyS and TNLG7A, is a member of TNF ligand superfamily. TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma...
TMPK-01165 MCEMP1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or down...
TMPK-01137 FAM3D Protein, Human, Recombinant (hFc) Human HEK293 Cells
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (m...
TMPJ-00397 IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to I...
TMPY-06836 NR3C1 Protein, Human, Recombinant (His) Human E. coli
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements ...
TMPY-01466 S100A12 Protein, Human, Recombinant Human E. coli
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01879 S100A14 Protein, Human, Recombinant (His) Human E. coli
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-04260 P38 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as prol...
TMPY-01000 BVES Protein, Human, Recombinant (GST) Human E. coli
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...
TMPY-01816 Pentraxin 3 Protein, Human, Recombinant (His) Human HEK293 Cells
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin dom...
TMPY-04391 Lyn Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many f...
TMPY-04550 JNK2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm...
TMPY-01926 S100A10 Protein, Human, Recombinant (His) Human E. coli
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
M-CSF/CSF1 Protein, Human, Recombinant (His)
TMPJ-00327
Species: Human
Expression System: HEK293 Cells
RON/CD136 Protein, Human, Recombinant (His)
TMPY-02028
Species: Human
Expression System: HEK293 Cells
BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc)
TMPJ-00623
Species: Rhesus
Expression System: HEK293 Cells
MCEMP1 Protein, Mouse, Recombinant (hFc)
TMPK-01165
Species: Mouse
Expression System: HEK293 Cells
FAM3D Protein, Human, Recombinant (hFc)
TMPK-01137
Species: Human
Expression System: HEK293 Cells
IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00397
Species: Human
Expression System: HEK293 Cells
NR3C1 Protein, Human, Recombinant (His)
TMPY-06836
Species: Human
Expression System: E. coli
S100A12 Protein, Human, Recombinant
TMPY-01466
Species: Human
Expression System: E. coli
S100A14 Protein, Human, Recombinant (His)
TMPY-01879
Species: Human
Expression System: E. coli
p38 Protein, Human, Recombinant (His)
TMPY-04260
Species: Human
Expression System: Baculovirus Insect Cells
BVES Protein, Human, Recombinant (GST)
TMPY-01000
Species: Human
Expression System: E. coli
Pentraxin 3 Protein, Human, Recombinant (His)
TMPY-01816
Species: Human
Expression System: HEK293 Cells
Lyn Protein, Human, Recombinant (GST)
TMPY-04391
Species: Human
Expression System: Baculovirus Insect Cells
JNK2 Protein, Human, Recombinant (His)
TMPY-04550
Species: Human
Expression System: Baculovirus Insect Cells
S100A10 Protein, Human, Recombinant (His)
TMPY-01926
Species: Human
Expression System: E. coli
カタログ番号 製品名
L3800 NF-κB Signaling Compound Library

729 compounds
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L9000 Apoptosis Compound Library

1760 compounds
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;